Zhen LI, Ph.D.

Professor

1988             Wuhan University                             B.S.

1995             Carnegie-Mellon University, USA                  Ph.D.

1995-1997    University of Michigan, USA               Postdoctor

1997-1999  Stanford University, USA                  Postdoctor

2000-2003    HKUST, Hong Kong                          Research Associate

2004-Present School of Life Sciences, Tsinghua University       Associate Professor, Professor

Research interest

Molecular mechanism of adiponectin

multimerization and secretion

Adiponectin-targeted drug development for Type 2 diabetes

Selected publications

1. Chen F, Huang Y, Luo L, Wang Q, Huang N, Zhang ZJ, Li Z. 2023. Comprehensive comparisons between grafted Kynam Agarwood and normal Agarwood on traits, composition, and in vitro activation of AMPK. Molecules. 228(4):1667-1686.

2. Zhang YD, Wang YY, Li, XC, Gu, KR, Li MX, Zhang Y, Zhang ZJ, Wang SF, Li Z. 2020. WSF-7 inhibits obesity-mediated PPARgamma phosphorylation and improves insulin sensitivity in 3T3-L1 adipocytes. Biol Pharm Bull. 43(3):526-532.

3. Wang Y, Zhang Y, Wang Y, Peng H, Rui J, Zhang Z, Wang S, Li Z. 2017. WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes. Biosci Biotechnol Biochem. 81(8):1529-1535.

4. Liu LH, Xie JY, Guo WW, Wu GY, Chen ZF, Yi JY, Zhang L, Zhang ZJ, Li Z.2014. Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes. J Asian Nat Prod Res. 16(11):1074-83.

5. Wu G, Yi J, Liu L, Wang P, Zhang Z, Li Z. 2013. Pseudoginsenoside F11, a Novel Partial PPARγ Agonist, Promotes Adiponectin Oligomerization and Secretion in 3T3-L1 Adipocytes. PPAR Res. Epub 2013 Dec 18.

6. Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. 2012. Promotion of adiponectin multimerization by emodin, a novel AMPK activator with PPARγ-agonist activity. J Cell Biochem. 113(11):3547-58.

7. Lin H, Li Y, Li Y, Yi J, Mai Y, Li Z. 2012. Tanshinone IIA promotes the assembly of adiponectin in 3T3-L1 adipocytes. Chin J of Nat Med. 10(2):150-154.

8. Lin H, Li Z. 2012. Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanism? Med Hypotheses. 78(1):75-8.

9. Li Y, Wang P, Zhuang Y, Lin H, Li Y, Liu L, Meng Q, Cui T, Liu J, Li Z. 2011. Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes. FEBS Lett. 585(12):1735-40.

Contact information

TEL/FAX：+86-10-62770581

E-mail:lizhen@mail.tsinghua.edu.cn